superoxide dismutase catalase and glutathione peroxidase Reactive Oxygen Species‐Induced Lipid Peroxidation in Apoptosis, Autophagy, Ferroptosis - Su - 2019 - Oxidative Medicine and Cellular Longevity First line defence antioxidants-superoxide dismutase

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He S, Liao TT, Chen YT, et al

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Pathways related to immunoglobulin, production, defense responses and B cell activation were among those downregulated, including immunoglobulin production ( IGKV112 , IGKV117 ), adaptive immune response (for example, CX3CR1 , FCGR1BP ) and B cell activation ( HDAC9 , CD180 , MNDA ) (Extended Data Fig

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Topical application may offer localised antioxidant benefits, but it cannot raise systemic glutathione levels the way oral supplementation does